Bulldogs and Anemia
Anemia is the
condition in which there are fewer red blood cells than normal.
Hemolytic anemia describes the condition in which this loss of
red blood cells occurs because the red cells break up (lyse).
This can happen inside the blood vessels (intravascular hemolysis)
or outside of the blood vessel (extravascular hemolysis). Hemolytic
anemia can occur for many reasons, including heat stroke, parasites,
viral infections. toxins and other conditions. One of the things
that can cause hemolytic anemia is immune system disease --- in
this case the disorder is known as immune mediated hemolytic anemia
(IMHA). This is the term currently preferred for the condition
formerly known as auto-immune hemolytic anemia (AIHA). The reason
for the subtle name change is the recognition that much of the
time the immune system really is attacking an invader -- it just
happens to be one that is stuck on the red blood cell so both
occurs for a number or reasons but they break down into two major
categories. Either blood is not being made in the first place
(nonregenerative anemia) or else it is being destroyed in some
manner even though it is being made by the body. If the destruction
outpaces the production, anemia occurs.
failure, bone marrow disorders, some cancers, some toxins, inherited
disorders, ehrlichiosis, drug reactions and iron deficiency can
all lead to non-regenerative anemias.
failure, heat stroke, iron deficiency, trauma, immune mediated
hemolytic anemia, drug reactions, babesiosis, hemobartenollosis,
inherited hemolytic anemias, intestinal parasites (hookworms,
esp.) and bleeding disorders (such as von Willebrand's disease)
can all lead to regenerative anemias. Even severe flea infestation
can cause significant anemia in young dogs.