is one of the most commonly used tranquilizers in veterinary medicine.
It is a phenothiazine compound. Its mode of action is only partially
understood but it involves blockage of dopamine nerve receptors
in the brain. It causes tranquilization and also has an anti-emetic
effect. This makes it especially useful for treating car sickness,
since that is often a combination of fear and motion sickness
recommended dosage for acepromazine is 0.25mg to 1mg per pound
of body weight. In most cases it is not necessary to use the higher
dosages. That is not true for use in trying to control fear based
aggression. Acepromazine is considered to be very safe. The average
toxic dose is significantly higher than the recommended dosage
(at least 20 times the dose). Despite this, acepromazine does
have some significant effects that must be considered. It can
cause hypotension (lowering of blood pressure). This effect may
be exaggerated in Boxers and there have been anecdotal reports
of death of Boxers after the use of acepromazine. In addition,
acepromazine seems to make it easier for dogs with seizure disorders
to have a seizure. This medication should not be used near the
time of dipping or treatment with organophosphates for flea control.
doesn't have any pain-killing effects. Many dogs seem to be able
to will themselves to overcome its effects, at least temporarily.
This makes it less than ideal as a drug for dealing with aggressive
or fearful dogs but there have not been better alternatives for
medicating prior to the visit. It works often enough that many
vets will try this approach first. We do this when we think it
has a chance of helping make an office visit go easier. We just
remember to continue to be very careful when examining the dog.
We do not recommend the use of this product, especially with bull breeds